Process Development Engineering Scientific Associate (Contract) 21750

Vertex has established a new research site in Boston Seaport where research, development, and clinical manufacturing for cell and genetic therapies will be primarily based. Cell and genetic therapies represent two rapidly emerging therapeutic modalities with the potential to treat—and even cure—several of the Diseases Vertex is focused on include sickle cell disease, Duchenne muscular dystrophy, and type 1 diabetes. Further investment in a research site to advance these programs will be essential to Vertex’s continued and sustained leadership in these exciting approaches. At Vertex Cell and

Genetic Therapies (VCGT): our teams will bring together the best biology, technologies, and enhanced manufacturing capabilities to ensure we bring these cutting-edge transformative therapies to patients as quickly as possible.

General Summary:

Vertex seeks a highly skilled individual to join our Process Development Core team as a contractor. In this pivotal role, you will spearhead the production and process development for high quality media, Cell Therapy process intermediates, drug product to support Cell and Gene Therapy portfolio . As a contractor scientist, you will play a significant part in our internal process development work, establishing schedule and maintenance of embryonic stem cell process, This position, based in our Boston, MA facilities, offers a unique opportunity to substantially impact Vertex's mission to bring innovative therapies to patients. The Process Development group offers a dynamic and challenging environment, perfect for individuals who thrive in fast-paced, high-energy settings. The ideal candidate will be a subject matter expert in Upstream processing or a relevant field(s) with a solid technical operations background.

 Ideal candidate will have experience with upstream manufacturing, Mamillian Cell Culture, and Stem Cell.

Key Responsibilities:

• Execute experiments to develop robust manufacturing processes for cell therapy products and implement them to support clinical development programs. Manage and execute routine pluripotent stem cell culture expansion and differentiation to support process development, optimization, and characterization.
• Run and establish lab capabilities for producing allogenic and autologous cell therapy process intermediates and DS/DP material using established procedures
• Manage project scheduling, project deliverables, conduct routine troubleshooting, RCA with a high degree of complexity.
• Document experimental procedures and results according to established guidelines. Perform statistical analysis of experimental data to determine critical process parameter ranges.
• Collaborate effectively within departmental teams and contribute to deliverables in a cross-functional environment,
• Coordinate resources and set priorities for own team, contributing to the department's overall goals.

Requirements:

• BS in Biochemistry, Engineering, Biology, or related discipline with 2-3 years of industry experience; an MS with 1+ years of industry experience
• Ability to run and design an experiment related to cell therapy with the goal of process improvement: routine cell passaging and expansion in 2D(adherent) and 3D(suspension)
• Able to independently execute, analyze, and document cell culture processes for biologics and cell therapy products.
• Experience working with stem cells, mammalian cell culture processing and bioreactors.
• Working knowledge of GLP, GMP requirements to support manufacturing activities
• Excellent verbal and written communication skills and ability to handle multiple tasks while meeting timelines and adapting to changing priorities.
• Strong organizational skills and high attention to detail.
• Periodic weekend rotational work to support cell culture activities will be required.

$30-38/hr

This job posting is for a temporary role with a third-party agency partner on assignment at Vertex Pharmaceuticals (“Vertex”). The individual selected for this role will be offered the role as an employee of a third- party agency partner; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency partner upon offer. The pay rate range provided is a reasonable estimate of the anticipated compensation range for this job at the time of posting. The actual pay rate will be based on a number of factors, including skills, competencies, experience, location and/or being pursued and other job-related factors permitted by law. In addition, this role will be eligible for overtime pay, in accordance with federal and state requirements

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