Research Scientist, Integrated Pharmacology (Contract)

Research Scientist, Integrated Pharmacology, Vertex Pharmaceuticals (Boston)
We seek a highly independent, collaborative and innovative scientist to join the Quantitative Cellular Pharmacology team in the Integrated Pharmacology group at Vertex Pharmaceuticals. The ideal candidate will be self-motivated with a strong foundation in cell biology and/or biochemistry and have experience with cell-based/biochemical assays. The successful candidate will be responsible for developing human disease-relevant assays to understand and address the underlying cause of serious life-threatening diseases. Target identification/validation, mechanism of action studies and understanding drug candidate pharmacology using innovative approaches and technologies will be required. Experience with miniaturized assays (384), knowledge of multiplex assay platforms, multi-parametric data analysis and basic command line programming is a plus. Preference will be given to candidates with a track record of innovation in the field. The Integrated Pharmacology group supports late-stage drug discovery for all disease areas in the Vertex drug discovery portfolio at the Boston site and the Research Scientist will be a member of multiple discovery project teams.

Key Responsibilities:
• Lead the development of cell-based and/or biochemical assays for small molecule discovery as a key member of discovery project teams
• Execute cell based and/or biochemical assays supporting medicinal chemistry optimization, characterize our lead molecules in in vitro/in vivo models of human disease and meet deliverables for preclinical development projects
• Analyze, critically interpret and present data to cross-functional project teams, and recommend courses of action based on datasets and discussions with biologists and chemists
• Propose and develop innovative approaches to small molecule discovery based on the latest technologies and publications in the field
• Identify and evaluate new technologies to improve efficiency and processes
• Strong interpersonal, verbal and written communication skills
• Be a key member of the Integrated Pharmacology group and serve as a strong representative on interdisciplinary project teams
• Ensure data integrity and compliance under Vertex policies

Minimal Requirements:
• PhD (or equivalent degree) in a relevant discipline (Cell Biology, Molecular Biology, Pharmacology, Biochemistry or related Biological Sciences) and 0-5 years of productive, relevant industry or postdoctoral experience in cell-based and/or biochemical assays to lead discovery, optimization and characterization
• Strong understanding of Cell Biology and expertise in cell-based and/or biochemical assay development
• Self-motivation, independence, organization, effective communication and presentation skills; adept in solving/troubleshooting complex problems as well as the ability to navigate a fast-paced work environment• A desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society

Vertex is a global biotechnology company that aims to discover, develop and commercialize innovative medicines so people with serious diseases can lead better lives. In addition to our clinical development programs focused on cystic fibrosis, Vertex has more than a dozen ongoing research programs aimed at other serious and life-threatening diseases.
Founded in 1989 in Cambridge, Mass., Vertex today has research and development sites and commercial offices in the United States, Europe, Canada and Australia. For four years in a row, Science magazine has named Vertex one of its Top Employers in the life sciences. For additional information and the latest updates from the company, please visit www.vrtx.com.

$47 - $50/HR

This job posting is for a temporary role with a third-party agency partner on assignment at Vertex Pharmaceuticals (“Vertex”). The individual selected for this role will be offered the role as an employee of a third- party agency partner; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency partner upon offer. The pay rate range provided is a reasonable estimate of the anticipated compensation range for this job at the time of posting. The actual pay rate will be based on a number of factors, including skills, competencies, experience, location and/or being pursued and other job-related factors permitted by law. In addition, this role will be eligible for overtime pay, in accordance with federal and state requirements

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