Protein Sciences Senior Research Scientist (Protein Engineering) (Contract)

General Summary:

The Vertex Seattle site is seeking a talented and motivated Protein Engineer (Senior Scientist) to join their dynamic team. If you are passionate about advancing scientific research and developing novel therapeutics, this role is for you!

Key Duties and Responsibilities:

• Design and execute protein engineering/directed evolution campaigns to improve binding affinity, stability, and selectivity.
• Utilize yeast surface display technology for library screening and directed evolution.
• Drawing from a deep array of Rosetta scripts and machine learning tools, create computational design strategies to deliver protein drug candidates.
• Effectively communicate design strategies to interdisciplinary team members.
• Collaborate with cross-functional teams to optimize protein candidates for function, manufacturability, and immunogenicity.
• Prepare reports, papers, and patent applications, collaborating closely with inventors, scientists, and legal counsel.

Knowledge and Skills:

• Strong understanding of the biophysics of protein structure/function relationships
• Proven experience in directed evolution, yeast surface display, and protein engineering.
• Demonstrated proficiency in protein modeling and design utilizing Rosetta software suite, Alphafold2, ColabFold, Protein MPNN, RFdiffusion or equivalent tools for insilico protein engineering
• Strong analytical skills and attention to detail
• Excellent communication and teamwork abilities
• Familiarity with antibody engineering and affinity maturation
• Experience in cellular assay development
• Understanding of cell biology and immunology

Education and Experience:

• Ph.D. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 2-5 years of relevant post-doctoral, industry employment experience, or
• M.S. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 5+ years of relevant industry employment experience, or
• B.S. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 8+ years of relevant industry employment experience

This position will be based out of Vertex's Seattle site location focused on protein engineering for the organization.

Contract Length: 6 months

$55/hr. - $88/hr.

This job posting is for a temporary role with a third-party agency partner on assignment at Vertex Pharmaceuticals (“Vertex”). The individual selected for this role will be offered the role as an employee of a third- party agency partner; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency partner upon offer. The pay rate range provided is a reasonable estimate of the anticipated compensation range for this job at the time of posting. The actual pay rate will be based on a number of factors, including skills, competencies, experience, location and/or being pursued and other job-related factors permitted by law. In addition, this role will be eligible for overtime pay, in accordance with federal and state requirements

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If you do not agree with the Atrium Terms and Conditions, you can still complete your application for this position by emailing your resume to our team at tempstaffing@vrtx.com. Please include the job title in the subject of your email.

No C2C or Third-Party Vendors