Proteomics Research Scientist

Responsibilities

• Develop, optimize, and implement targeted proteomics analysis workflows, including automated enrichment strategies, for precise, accurate, and sensitive protein measurements using stable isotope dilution and label-free mass spectrometry
• Coordinate with project teams to identify targeted proteomics assay requirements, timing, samples and deliverables
• Perform targeted protein MS assays using state-of-the-art LC-MS systems; including nano-LC, Orbitrap MS platforms to determine protein concentrations in cells or tissues
• Prepare samples from a wide variety of biological matrices (cultured cells, tissues, plasma, biofluids) from human and preclinical species using manual and automated bead-based workflows
• Perform data analysis utilizing a range of proteomics software (Skyline, MaxQuant, DIANN, Spectronaut)
• Maintain and qualify HPLC and MS instrument performance

Qualifications

• PhD in Biochemistry, Biology, Chemistry, Chemical Biology with minimally 2 years of experience in targeted mass spectrometry-based proteomics in industry or startup biotech setting or MS with 5 + years of experience
• Broad experience in targeted MS is required
• Hands on experiences on targeted MS method development and execution, including highly multiplexed and sensitive PRM stable isotope labeled peptide assays using DDA and DIA data
• Hands on experiences in operating, maintaining and troubleshooting nanoLC and Orbitrap MS instruments
• Hands-on experience in sample preparation method development and optimization from various matrices (cells, tissues, plasma, biofluids)
• Demonstrated ability to independently analyze, and interpret targeted proteomics data, and communicate effectively in a fast paced, team-oriented environment
• Experiences in expression proteomics and chemoproteomics are highly desirable
• Demonstrated ability to develop methods and lead mechanism of action mass spectrometry studies
• Develop and optimize mass spectrometry screening assays based on project needs
• Experience with sample preparation from primary cells is a plus
• Motivated problem solver with attention to details, great organization skills and time management,  and ability to multitask efficiently to meet drug discovery timelines, team player

$60-$70/HR

This job posting is for a temporary role with a third-party agency partner on assignment at Vertex Pharmaceuticals (“Vertex”). The individual selected for this role will be offered the role as an employee of a third- party agency partner; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency partner upon offer. The pay rate range provided is a reasonable estimate of the anticipated compensation range for this job at the time of posting. The actual pay rate will be based on a number of factors, including skills, competencies, experience, location and/or being pursued and other job-related factors permitted by law. In addition, this role will be eligible for overtime pay, in accordance with federal and state requirements

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